Microfluidics co-culture systems for studying tooth innervation

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Microfluidics co-culture systems for studying tooth innervation

Innervation plays a key role in the development and homeostasis of organs and tissues of the orofacial complex. Among these structures, teeth are peculiar organs as they are not innervated until later stages of development. Furthermore, the implication of neurons in tooth initiation, morphogenesis and differentiation is still controversial. Co-cultures constitute a valuable method to investigat...

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Innervation plays a key role in the development, homeostasis and regeneration of organs and tissues. However, the mechanisms underlying these phenomena are not well understood yet. In particular, the role of innervation in tooth development and regeneration is neglected. Several in vivo studies have provided important information about the patterns of innervation of dental tissues during develo...

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ژورنال

عنوان ژورنال: Frontiers in Physiology

سال: 2014

ISSN: 1664-042X

DOI: 10.3389/fphys.2014.00326